• DOI:10.1177/1091581809350933
• Corpus ID: 23262031

Final Report on the Safety Assessment of PPG-2 Methyl Ether, PPG-3 Methyl Ether, and PPG-2 Methyl Ether Acetate

@article{Robinson2009FinalRO,
  title={Final Report on the Safety Assessment of PPG-2 Methyl Ether, PPG-3 Methyl Ether, and PPG-2 Methyl Ether Acetate},
  author={Valerie C. Robinson and Wilma Fowler Bergfeld and Donald V. Belsito and Curtis D. Klaassen and James G. Marks and Ronald C. Shank and Thomas J. Slaga and Paul W. Snyder and F. Alan Andersen},
  journal={International Journal of Toxicology},
  year={2009},
  volume={28},
  pages={162S - 174S}
}

• V. Robinson, W. Bergfeld, +6 authors F. A. Andersen
• Published 1 November 2009
• Chemistry
• International Journal of Toxicology

PPG-2 methyl ether, PPG-3 methyl ether, and PPG-2 methyl ether acetate are used in cosmetics as fragrance ingredients and/or solvents at concentrations of 0.4% to 2%. Propylene glycol ethers are rapidly absorbed and distributed throughout the body when introduced by inhalation or oral exposure, but the inhalation toxicity of PPG-2 methyl ether vapor, for example, is low. Aerosols, such as found with hair sprays, produce particle sizes that are not respirable. Because these ingredients are highly water-soluble, they are likely to be absorbed through the human skin only at slow rates, resulting in low blood concentrations and rapid removal by the kidney. These ingredients are not genotoxic and are not reproductive or developmental toxicants. Overall the data are sufficient to conclude that PPG-2 methyl ether, PPG-3 methyl ether, and PPG-2 methyl ether acetate are safe as used in cosmetics.