Final Report on the Safety Assessment of EDTA, Calcium Disodium EDTA, Diammonium EDTA, Dipotassium EDTA, Disodium EDTA, TEA-EDTA, Tetrasodium EDTA, Tripotassium EDTA, Trisodium EDTA, HEDTA, and Trisodium HEDTA

@article{Lanigan2002FinalRO,
  title={Final Report on the Safety Assessment of EDTA, Calcium Disodium EDTA, Diammonium EDTA, Dipotassium EDTA, Disodium EDTA, TEA-EDTA, Tetrasodium EDTA, Tripotassium EDTA, Trisodium EDTA, HEDTA, and Trisodium HEDTA},
  author={Rebecca S Lanigan and Torill A Yamarik},
  journal={International Journal of Toxicology},
  year={2002},
  volume={21},
  pages={142 - 95}
}
EDTA (ethylenediamine tetraacetic acid) and its salts are substituted diamines. HEDTA (hydroxyethyl ethylenediamine triacetic acid) and its trisodium salt are substituted amines. These ingredients function as chelating agents in cosmetic formulations. The typical concentration of use of EDTA is less than 2%, with the other salts in current use at even lower concentrations. The lowest dose reported to cause a toxic effect in animals was 750 mg/kg/day. These chelating agents are cytotoxic and… Expand
Short review of Calcium Disodium ethylene diamine tetra acetic acid as a food additive.
Calcium disodium ethylenediaminetetraacetate (Calcium Disodium EDTA, C10H12CaN2Na2O8.2H2O) is a derivative of EthylenediamineTetraacetic Acid and is an approved food additive (E385). It is used asExpand
Final Report of the Cosmetic Ingredient Review Expert Panel Amended Safety Assessment of Dodecylbenzenesulfonate , Decylbenzenesulfonate , and Tridecylbenzenesulfonate Salts as Used In Cosmetics March
Sodium Dodecylbenzenesulfonate is one of a group of salts of alkylbenzene sulfonates used in cosmetics as surfactantcleansing agents. Sodium Dodecylbenzenesulfonate is soluble in water and partiallyExpand
Comparative in vitro studies on disodium EDTA effect with and without Proteus mirabilis on the crystallization of carbonate apatite and struvite
Abstract Effect of disodium EDTA (salt of ethylenediamine tetraacetic acid) on the crystallization of struvite and carbonate apatite was studied. To evaluate such an effect we performed an experimentExpand
EDTA (Ethylenediaminetetraacetic Acid)
Ethylenediaminetetraacetic acid (EDTA) (60-00-4) was developed by Franz Munz in Germany during the 1930s as an alternative to citric acid. About the same time, Frederick Bersworth synthesized EDTA inExpand
Amended Safety Assessment of Dodecylbenzenesulfonate, Decylbenzenesulfonate, and Tridecylbenzenesulfonate Salts as Used in Cosmetics
TLDR
The Cosmetic Ingredient Review Expert Panel concluded that the irritant properties of these ingredients are similar to those of other detergents, with severity dependent on concentration and pH. Expand
Reasons for raising the maximum acceptable daily intake of EDTA and the benefits for iron fortification of foods for children 6–24 months of age
TLDR
Raising the maximum ADI of EDTA to only 4.4 mg day−1 kgbw−1 would enable iron EDTA, an iron fortificant with proven bioavailability in phytate‐rich meals, to be added in adequate amounts to cereal‐based meals for children 6–24 months of age, who are at risk of iron deficiency. Expand
Dechelation of Cd-EDTA complex and recovery of EDTA from simulated soil-washing solution with sodium sulfide.
TLDR
The results showed that the effect of Na2S dosage on the dechelation of Cd-EDTA solution was greater than that of other factors (reaction temperature, time, and pH) and excess EDTA suppressed cadmium removal and the recovered EDTA with acidification had the same ability to extract heavy metals from soil with fresh EDTA. Expand
Toxicity of bean cooking media containing EDTA in mice
TLDR
It is demonstrated that EDTA in bean cooking is harmful in mice under the conditions of this study, and the potentially harmful effects in humans supports restricting its use. Expand
Final Report on the Safety Assessment of Pentasodium Pentetate and Pentetic Acid as Used in Cosmetics
TLDR
Data from short-term studies of the calcium and sodium salts of Pentetic Acid in male mice demonstrated no dose-related toxicity over the dose range of 10, 100, and 250 mg/kg, and these data were considered sufficient to support the safety of Pentesodium Pentetate and Pentetic acid as used in cosmetics. Expand
Influence of Chelating Agents on Fenton-Type Reaction Using Ferrous Ion and Hypochlorous Acid
Iron-based advanced oxidation technologies, such as the Fenton process, are widely used for industrial wastewater treatment. However, wastewater sometimes contains chelating agents such asExpand
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References

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The relative toxicity in rats of disodium ethylene diamine tetra‐acetate, sodium oxalate and sodium citrate
TLDR
A study of the relative toxicity of disodium EDTA and sodium oxalate when administered intravenously to rats might reveal the nature of the mechanisms involved in the removal of calcium from the plasma. Expand
The effect of ethylenediaminetetraacetic acid (EDTA) and EDTA plus salicylate on acute cadmium toxicity and distribution.
TLDR
EDTA, in dosages as low as 0.3 mmol/kg, significantly decreased the concentration of Cd found in most tissues, and the addition of sodium salicylate to the chelator therapy did not significantly alter tissue Cd concentrations when compared to that found in mice given EDTA alone. Expand
The toxicity and pharmacodynamics of EGTA: oral administration to rats and comparisons with EDTA.
TLDR
EGTA was better tolerated in the diet and appeared to be less irritating and less toxic than EDTA. Expand
Assessment of in vivo mutagenic potency of ethylenediaminetetraacetic acid in albino mice.
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  • Chemistry, Medicine
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  • 1991
TLDR
Treatment of male mice with EDTA disodium salt induced no increase in the incidence of post-implantation embryonic deaths, except for a marginal but statistically insignificant increase during wk 2 and 3 of mating. Expand
Teratogenic effect of calcium edetate (CaEDTA) in rats and the protective effect of zinc.
TLDR
It was concluded that CaEDTA is teratogenic in rats at concentrations which, except for decreased weight gain, produce no discernible toxicity to the dam, and which are comparable to the recommended therapeutic dosage in humans (1500 mg/m2/day corresponding to 4 mmol/m 2/day). Expand
Comparison of the effects of sodium salicylate, disodium ethylenediaminetetraacetic acid and polyoxyethylene−23−lauryl ether as adjuvants for the rectal absorption of sodium cefoxitin
TLDR
It appears that the effects of salicylate occur at the protein fraction of the rectal mucosa through a saturable process whereas the adjuvant action of POE and EDTA appears to involve some irreversible disruption of the membrane. Expand
Genetic toxicology of ethylenediaminetetraacetic acid (EDTA).
TLDR
Although EDTA produces a whole set of genetic effects it seems to be a harmless compound to man as far as genotoxicity is concerned, the data presently at hand are not sufficient for a reliable risk assessment. Expand
A comparative study of the toxic effects of calcium and chromium chelates of ethylenediaminetetraacetate in the dog.
TLDR
The results indicate CaEDTA is not primarily nephrotoxic in the dog and, therefore, renal failure probably is not the cause of death and the infusion of a very stable chelate, CrEDTA, was nontoxic. Expand
Effect of route of administration on the toxicity and teratogenicity of EDTA in the rat.
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TLDR
Differences in toxicity and teratogenicity are absorption into the circulation, interaction with essential metals, and the stress associated with administration of the compound. Expand
Effect of calcium and chromium chelates of ethylenediaminetetraacetate on intestinal permeability and collagen metabolism in the rat.
TLDR
It seems that CaEDTA effects collagen degradation by virtue of its chelating property, and no significant changes in metal concentrations of the intestinal wall were measured, but the study did not rule out the possibility of an inactivation of metals in situ due to the formation of ternary complexes. Expand
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