Final Report of the Safety Assessment of Isobutane, Isopentane, n-Butane, and Propane

@article{1982FinalRO,
  title={Final Report of the Safety Assessment of Isobutane, Isopentane, n-Butane, and Propane},
  author={},
  journal={International Journal of Toxicology},
  year={1982},
  volume={1},
  pages={127 - 142}
}
  • Published 1 July 1982
  • Chemistry
  • International Journal of Toxicology
Isobutane, Isopentane, n-Butane, and Propane are low molecular weight alkanes, generally used in cosmetic products as aerosol propellants. Isobutane, Isopentane, n-Butane, and Propane were found not to be mutagenic in Ames Tests, both with and without metabolic activation. In eye irritation studies in rabbits, Isobutane caused very slight iridial and corneal irritation. Both n-Butane and Propane were mildly to moderately irritating to the skin of rabbits. Isobutane, at 22% in a hair spray, was… 
The Toxicological Properties of Petroleum Gases
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There was no evidence of effects on developmental or reproductive toxicity in the studies of ethane, propane, or n-butane at the highest concentrations tested, and a method is proposed by which the toxicity of any of the 106 complex petroleum gas streams can be estimated from its composition.
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Butane (both isomers) [MAK Value Documentation, 2003]
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  • 2003
MAK value (1966) 1000 ml/m (ppm)  2400 mg/m Peak limitation (1983) Category II, excursion factor 4 Absorption through the skin – Sensitization – Carcinogenicity – Prenatal toxicity (1999) see
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The Cosmetic Ingredient Review (CIR) Expert Panel has reviewed relevant animal and clinical data and concluded that these ingredients are safe in the present practices of use and concentration described in this safety assessment.
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According to the study, butane may create inflammation in nasal mucosa and be present as propellant gas in deodorants, shaving foam tubes, air fresheners.

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