Filtration of chylomicrons by the liver may influence cholesterol metabolism and atherosclerosis.

@article{Fraser1978FiltrationOC,
  title={Filtration of chylomicrons by the liver may influence cholesterol metabolism and atherosclerosis.},
  author={Robin Fraser and Andrew G. Bosanquet and William A. Day},
  journal={Atherosclerosis},
  year={1978},
  volume={29 2},
  pages={113-23}
}
A fenestrated endothelial lining of sinusoids in rat liver has been shown to separate chylomicrons of different sizes following their injection into the portal vein. This sieving may have physiological importance, since during low dietary fat intake some intestinal lipoproteins are probably small enough to contact liver cells, but during high dietary fat loads most chylomicrons are too large to pass through the filter and must first be degraded to smaller remnants. The liver plays a central… CONTINUE READING