Filtration failure induced by p-aminophenol in rats is due to raised intratubular pressure and not changes in glomerular function.

Abstract

1. The p-aminophenol (pAP) model of tubular necrosis displays elevated tubular pressures equivalent to 'stop-flow', with low glomerular filtration rate (GFR) but maintained blood flow and urine output. Renal function, micropuncture, and morphological studies were performed in anaesthetized rats to examine the causes of filtration failure. 2. At the height… (More)

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Cite this paper

@article{Henry1990FiltrationFI, title={Filtration failure induced by p-aminophenol in rats is due to raised intratubular pressure and not changes in glomerular function.}, author={Maria A.C.A. Henry and Phillip J. Harris and Robert J Naughton and Linda L. Walker and Sandford L. Skinner and Junko Tange}, journal={Clinical and experimental pharmacology & physiology}, year={1990}, volume={17 9}, pages={613-26} }