Filtering of deep sequencing data reveals the existence of abundant Dicer-dependent small RNAs derived from tRNAs.

@article{Cole2009FilteringOD,
  title={Filtering of deep sequencing data reveals the existence of abundant Dicer-dependent small RNAs derived from tRNAs.},
  author={Christian Cole and Andrew E Sobala and Cheng Lu and Shawn R. Thatcher and Andrew Bowman and John W. S. Brown and Pamela J. Green and Geoffrey J. Barton and Gyorgy Hutvagner},
  journal={RNA},
  year={2009},
  volume={15 12},
  pages={2147-60}
}
Deep sequencing technologies such as Illumina, SOLiD, and 454 platforms have become very powerful tools in discovering and quantifying small RNAs in diverse organisms. Sequencing small RNA fractions always identifies RNAs derived from abundant RNA species such as rRNAs, tRNAs, snRNA, and snoRNA, and they are widely considered to be random degradation products. We carried out bioinformatic analysis of deep sequenced HeLa RNA and after quality filtering, identified highly abundant small RNA… CONTINUE READING
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