Filter flexibility in a mammalian K channel: models and simulations of Kir6.2 mutants.

@article{Capener2003FilterFI,
  title={Filter flexibility in a mammalian K channel: models and simulations of Kir6.2 mutants.},
  author={Charlotte E. Capener and Peter Proks and Frances M. Ashcroft and Mark S. P. Sansom},
  journal={Biophysical journal},
  year={2003},
  volume={84 4},
  pages={2345-56}
}
The single-channel conductance varies significantly between different members of the inward rectifier (Kir) family of potassium channels. Mutations at three sites in Kir6.2 have been shown to produce channels with reduced single-channel conductance, the largest reduction (to 40% of wild-type) being for V127T. We have used homology modeling (based on a KcsA template) combined with molecular dynamics simulations in a phosphatidycholine bilayer to explore whether changes in structural dynamics of… CONTINUE READING

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