Filopodia are conduits for melanosome transfer to keratinocytes.

  title={Filopodia are conduits for melanosome transfer to keratinocytes.},
  author={Glynis A. Scott and Sonya Leopardi and Stacey Printup and Brian Madden},
  journal={Journal of cell science},
  volume={115 Pt 7},
Melanosomes are specialized melanin-synthesizing organelles critical for photoprotection in the skin. Melanosome transfer to keratinocytes, which involves whole organelle donation to another cell, is a unique biological process and is poorly understood. Time-lapse digital movies and electron microscopy show that filopodia from melanocyte dendrites serve as conduits for melanosome transfer to keratinocytes. Cdc42, a small GTP-binding protein, is known to mediate filopodia formation. Melanosome… CONTINUE READING

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