Filling the pipeline - new drugs for an old disease.

  title={Filling the pipeline - new drugs for an old disease.},
  author={Matthias Stehr and Ayssar A. Elamin and Mahavir Singh},
  journal={Current topics in medicinal chemistry},
  volume={14 1},
Tuberculosis is a major global health problem. In the middle of the last century several laboratories identified, developed and synthesized several substances which were active against Mycobacterium tuberculosis, the causative agent of the disease. In the 1980s the standard oral treatment regimen was introduced with isoniazid, rifampicin, pyrazinamide, and ethambutol. In combination with the DOTS strategy it was possible treat TB within 6-8 months. But with the emergence of drug resistant… CONTINUE READING