Filia Is an ESC-Specific Regulator of DNA Damage Response and Safeguards Genomic Stability.

@article{Zhao2015FiliaIA,
  title={Filia Is an ESC-Specific Regulator of DNA Damage Response and Safeguards Genomic Stability.},
  author={Bo Zhao and Wei-Dao Zhang and Ying-Liang Duan and Yong-qing Lu and Yi-Xian Cun and Chao-Hui Li and Kun Guo and Wen-hui Nie and Lei Thor Li and Rugang Zhang and Ping Zheng},
  journal={Cell stem cell},
  year={2015},
  volume={16 6},
  pages={684-98}
}
Pluripotent stem cells (PSCs) hold great promise in cell-based therapy, but the genomic instability seen in culture hampers their full application. A greater understanding of the factors that regulate genomic stability in PSCs could help address this issue. Here we describe the identification of Filia as a specific regulator of genomic stability in mouse embryonic stem cells (ESCs). Filia expression is induced by genotoxic stress. Filia promotes centrosome integrity and regulates the DNA damage… CONTINUE READING
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