Filariasis: new drugs and new opportunities for lymphatic filariasis and onchocerciasis

@article{Hoerauf2008FilariasisND,
  title={Filariasis: new drugs and new opportunities for lymphatic filariasis and onchocerciasis},
  author={Achim Hoerauf},
  journal={Current Opinion in Infectious Diseases},
  year={2008},
  volume={21},
  pages={673–681}
}
  • A. Hoerauf
  • Published 2008
  • Medicine
  • Current Opinion in Infectious Diseases
Purpose of review Chemotherapy against onchocerciasis and lymphatic filariasis has been discussed mainly within the framework of mass drug administration with diethylcarbamazine, ivermectin and albendazole. Although strong reductions in infection prevalence were achieved, the regimes for these drugs do not fully cover needs of individual patients who seek treatment because of symptoms. Chemotherapy against filarial Wolbachia endosymbionts with doxycycline showed higher antiparasitic efficacy in… Expand
Chemotherapy of filariasis – established strategies and new developments
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TLDR
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References

SHOWING 1-10 OF 76 REFERENCES
Doxycycline in the treatment of human onchocerciasis: Kinetics of Wolbachia endobacteria reduction and of inhibition of embryogenesis in female Onchocerca worms.
TLDR
Due to its long-lasting inhibition of embryogenesis, doxycycline presents an additional strategy for the treatment of onchocerciasis and control of Onchocerca microfilariae transmission. Expand
Bancroftian filariasis: effect of repeated treatment with diethylcarbamazine and albendazole on microfilaraemia, antigenaemia and antifilarial antibodies.
TLDR
The results show that the studied parameters decline at different rates and to differing degrees following DEC/ALB treatment, which has important implications regarding strategies for monitoring the effects of MDA in populations. Expand
Antibiotic therapy in murine filariasis (Litomosoides sigmodontis): comparative effects of doxycycline and rifampicin on Wolbachia and filarial viability
TLDR
The combination of antirickettsial drugs could be used as a suitable tool to explore the minimum duration of therapy required for the depletion of Wolbachia in parasitized hosts subsequent to the onset of patency in human and animal filariasis and the prevention of adverse reactions in human infections. Expand
Efficacy of 5-week doxycycline treatment on adult Onchocerca volvulus
TLDR
Doxycycline cannot replace regular ivermectin mass treatment because new infections would require repeated rounds of doxycycline, but it can be used for the treatment of individuals outside transmission areas, in foci where iver mectin resistance may occur, and in countries where onchocerciasis and loiasis are co-endemic. Expand
Efficacy of 2- and 4-week rifampicin treatment on the Wolbachia of Onchocerca volvulus
TLDR
Embryogenesis and microfilariae production were reduced after 4 weeks rifampicin treatment, rendering rifampsicin an antibiotic with anti-wolbachial efficacy in human onchocerciasis. Expand
Strategies and tools for the control/elimination of lymphatic filariasis.
TLDR
New approaches to disease control, based on preventing bacterial superinfection, can now halt or even reverse the lymphoedema and elephantiasis sequelae of filarial infection. Expand
Macrofilaricidal activity after doxycycline treatment of Wuchereria bancrofti: a double-blind, randomised placebo-controlled trial
TLDR
An 8-week course of doxycycline is a safe and well-tolerated treatment for lymphatic filariasis with significant activity against adult worms and microfilaraemia. Expand
The chemotherapy of onchocerciasis XX: ivermectin in combination with albendazole.
TLDR
The combination of ivermectin with albendazole given one week apart is well tolerated but produces no additional effect against Onchocerca volvulus when compared to iver mectin given alone. Expand
Doxycycline treatment of Brugia malayi-infected persons reduces microfilaremia and adverse reactions after diethylcarbamazine and albendazole treatment.
  • T. Supali, Y. Djuardi, +6 authors E. Sartono
  • Medicine
  • Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 2008
TLDR
A 6-week course of doxycycline, either alone or in combination with diethylcarbamazine-albendazole, leads to a decrease in microfilaremia and reduces adverse reactions to antifilarial treatment in B. malayi-infected persons. Expand
Albendazole for lymphatic filariasis.
TLDR
There is insufficient evidence to confirm or refute that albendazole co-administered with DEC or ivermectin is more effective than DEC oriver mectin alone in clearing microfilariae or killing adult worms. Expand
...
1
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3
4
5
...