Filamins in cardiovascular development.

  title={Filamins in cardiovascular development.},
  author={Xianghua Zhou and Jan Bor{\'e}n and Levent M. Aky{\"u}rek},
  journal={Trends in cardiovascular medicine},
  volume={17 7},
Filamins are classically recognized as large cytoplasmic proteins that cross-link cortical actin into dynamic 3-dimensional structures and transmit extracellular signals through integrin receptors into the cytoplasm. However, recent reports indicate that filamins interact with a large number of other proteins with diverse functions, including transcriptional factors and cellular molecules involved in signaling, adhesion, and cellular motility, and are also present in the cell nucleus. In… CONTINUE READING

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