Filamins as integrators of cell mechanics and signalling

Abstract

Filamins are large actin-binding proteins that stabilize delicate three-dimensional actin webs and link them to cellular membranes. They integrate cellular architectural and signalling functions and are essential for fetal development and cell locomotion. Here, we describe the history, structure and function of this group of proteins.

DOI: 10.1038/35052082
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@article{Stossel2001FilaminsAI, title={Filamins as integrators of cell mechanics and signalling}, author={Thomas Peter Stossel and John S Condeelis and Lynn Cooley and John H. Hartwig and Angelika A. Noegel and Michael Schleicher and Sandor S. Shapiro}, journal={Nature Reviews Molecular Cell Biology}, year={2001}, volume={2}, pages={138-145} }