Filamin structure, function and mechanics: are altered filamin-mediated force responses associated with human disease?
- Andrew J. Sutherland-Smith
- Biophysical Reviews
Filamins are large actin-binding proteins that stabilize delicate three-dimensional actin webs and link them to cellular membranes. They integrate cellular architectural and signalling functions and are essential for fetal development and cell locomotion. Here, we describe the history, structure and function of this group of proteins.