Filamin A is a phosphorylation target of membrane but not cytosolic adenylyl cyclase activity.


Transmembrane adenylyl cyclase (AC) generates a cAMP pool within the subplasma membrane compartment that strengthens the endothelial cell barrier. This cAMP signal is steered toward effectors that promote junctional integrity and is inactivated before it accesses microtubules, where the cAMP signal causes phosphorylation of tau, leading to microtubule… (More)
DOI: 10.1152/ajplung.00417.2009


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