Filamin A-interacting protein (FILIP) regulates cortical cell migration out of the ventricular zone

@article{Nagano2002FilaminAP,
  title={Filamin A-interacting protein (FILIP) regulates cortical cell migration out of the ventricular zone},
  author={Takashi Nagano and Takunari Yoneda and Yumiko Hatanaka and Chikara Kubota and Fujio Murakami and Makoto Sato},
  journal={Nature Cell Biology},
  year={2002},
  volume={4},
  pages={495-501}
}
Precisely regulated radial migration out of the ventricular zone is essential for corticogenesis. Here, we identify a mechanism that can tether ventricular zone cells in situ. FILIP interacts with Filamin A, an indispensable actin-binding protein that is required for cell motility, and induces its degradation in COS-7 cells. Degradation of Filamin A is identified in the cortical ventricular zone, where filip mRNA is localized. Furthermore, most ventricular zone cells that overexpress FILIP fail… CONTINUE READING

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migration

  • S. K. McConnell, C. E. Kaznowski
  • 2000

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