Filamentous smooth muscle myosin is regulated by phosphorylation

@article{Trybus1989FilamentousSM,
  title={Filamentous smooth muscle myosin is regulated by phosphorylation},
  author={Kathleen M Trybus},
  journal={The Journal of Cell Biology},
  year={1989},
  volume={109},
  pages={2887 - 2894}
}
The enzymatic activity of filamentous dephosphorylated smooth muscle myosin has been difficult to determine because the polymer disassembles to the folded conformation in the presence of MgATP. Monoclonal antirod antibodies were used here to "fix" dephosphorylated myosin in the filamentous state. The steady-state actin-activated ATPase of phosphorylated filaments was 30-100-fold higher than that of antibody-stabilized dephosphorylated filaments, suggesting that phosphorylation can activate… CONTINUE READING
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