Filamentous hemagglutinin of Bordetella pertussis: a key adhesin with immunomodulatory properties?

@article{Romero2014FilamentousHO,
  title={Filamentous hemagglutinin of Bordetella pertussis: a key adhesin with immunomodulatory properties?},
  author={Rodrigo Villarino Romero and Radim Osicka and Peter {\vS}ebo},
  journal={Future microbiology},
  year={2014},
  volume={9 12},
  pages={
          1339-60
        }
}
The filamentous hemagglutinin of pathogenic Bordetellae is a prototype of a large two-partner-system-secreted and β-structure-rich bacterial adhesin. It exhibits several binding activities that may facilitate bacterial adherence to airway mucosa and host phagocytes in the initial phases of infection. Despite three decades of research on filamentous hemagglutinin, there remain many questions on its structure-function relationships, integrin interactions and possible immunomodulatory signaling… CONTINUE READING
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