Filamentous Bacteriophage Produced by Pseudomonas aeruginosa Alters the Inflammatory Response and Promotes Noninvasive Infection In Vivo.

@article{Secor2017FilamentousBP,
  title={Filamentous Bacteriophage Produced by Pseudomonas aeruginosa Alters the Inflammatory Response and Promotes Noninvasive Infection In Vivo.},
  author={Patrick R Secor and Lia A. Michaels and Kate S. Smigiel and Maryam G. Rohani and Laura K. Jennings and Katherine B. Hisert and Allison Arrigoni and Kathleen R. Braun and Timothy P. Birkland and Y. R. Lai and Teal S. Hallstrand and Paul L. Bollyky and Pradeep K. Singh and William C. Parks},
  journal={Infection and immunity},
  year={2017},
  volume={85 1}
}
Pseudomonas aeruginosa is an important opportunistic human pathogen that lives in biofilm-like cell aggregates at sites of chronic infection, such as those that occur in the lungs of patients with cystic fibrosis and nonhealing ulcers. During growth in a biofilm, P. aeruginosa dramatically increases the production of filamentous Pf bacteriophage (Pf phage). Previous work indicated that when in vivo Pf phage production was inhibited, P. aeruginosa was less virulent. However, it is not clear how… CONTINUE READING
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