Filaggrin repeat number polymorphism is associated with a dry skin phenotype

  title={Filaggrin repeat number polymorphism is associated with a dry skin phenotype},
  author={Rebecca S. Ginger and Sarah Blachford and Julie Rowland and Matthew J Rowson and Clive R. Harding},
  journal={Archives of Dermatological Research},
Profilaggrin is a key epidermal protein, critical for the generation and maintenance of the stratum corneum barrier. It is encoded by a gene located in the epidermal differentiation complex of Chromosome 1q21 and is composed of multiple filaggrin repeats connected by highly conserved linker peptides. Within the human population the number of filaggrin repeats encoded by this gene varies between 10, 11 or 12 repeats. Using a PCR-based approach we have determined individual profilaggrin… CONTINUE READING

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