Filaggrin null mutations are associated with increased asthma exacerbations in children and young adults

@article{Basu2008FilaggrinNM,
  title={Filaggrin null mutations are associated with increased asthma exacerbations in children and young adults},
  author={Kumar Kanti Basu and C N A Palmer and Brian J. Lipworth and W. H. Irwin McLean and Ana Terron-Kwiatkowski and Y Zhao and Haihui Liao and Frances J. D. Smith and Asis Mitra and Somnath Mukhopadhyay},
  journal={Allergy},
  year={2008},
  volume={63}
}
Background:  Filaggrin (FLG) null mutations are important genetic predisposing factors for atopic asthma and have recently been shown to influence controller and reliever medication needs in asthmatic children. Our objective was to study the role of FLG null alleles in asthma exacerbations. 
Filaggrin mutations increase allergic airway disease in childhood and adolescence through interactions with eczema and aeroallergen sensitization
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TLDR
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TLDR
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TLDR
Loss-of-function mutations in the filaggrin gene have commonly been described in patients with AD and are associated with an increased risk of atopic sensitization in these individuals leading to asthma and allergic rhinitis.
Filaggrin gene mutations and new SNPs in asthmatic patients: a cross-sectional study in a Spanish population
TLDR
In the association study of genetic variants of the FLG gene in a population of patients diagnosed with asthma the 1741A > T polymorphism seems to be associated with non-allergic asthma.
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References

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Filaggrin null mutations are associated with increased asthma severity in children and young adults.
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TLDR
The filaggrin variant alleles R501X and 2282del4 have repeatedly been shown to be associated with atopic dermatitis and any possible association with hand eczema or contact allergy are unexplored.
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TLDR
The data conclusively demonstrate that identification of FLG null alleles is an indicator of a poor prognosis in AD, predisposing to a form of eczema that starts in early infancy and persists into adulthood.
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TLDR
The importance of the epidermal barrier in preventing sensitization to allergens is suggested, and two common loss-of-function mutations in the gene encoding filaggrin are important risk factors for atopic dermatitis.
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TLDR
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Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis
TLDR
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