Filaggrin null mutations are associated with increased asthma exacerbations in children and young adults

@article{Basu2008FilaggrinNM,
  title={Filaggrin null mutations are associated with increased asthma exacerbations in children and young adults},
  author={Kumar Kanti Basu and C N A Palmer and Brian J. Lipworth and W. H. Irwin McLean and Ana Terron-Kwiatkowski and Y Zhao and Haihui Liao and Frances J. D. Smith and Asis Mitra and Somnath Mukhopadhyay},
  journal={Allergy},
  year={2008},
  volume={63}
}
Background:  Filaggrin (FLG) null mutations are important genetic predisposing factors for atopic asthma and have recently been shown to influence controller and reliever medication needs in asthmatic children. Our objective was to study the role of FLG null alleles in asthma exacerbations. 
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Filaggrin gene defects are associated with eczema, wheeze, and nasal disease during infancy: Prospective study.
Filaggrin mutations increase allergic airway disease in childhood and adolescence through interactions with eczema and aeroallergen sensitization
  • A. Chan, W. Terry, S. H. Arshad
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    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
  • 2018
TLDR
It is unclear whether FLG variants require both eczema and aeroallergen sensitization to influence airway disease development long‐term outcomes.
Individuals with filaggrin‐related eczema and asthma have increased long‐term medication and hospital admission costs
TLDR
Several loss‐of‐function mutations in filaggrin (FLG) have been identified in patients with eczema, however, the association of FLG with healthcare use is unknown.
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A FCER2 T2206C variant associated with chronic symptoms and exacerbations in steroid‐treated asthmatic children and its role in exacerbations is unclear.
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TLDR
Filaggrin gene variants and atopic diseases in early childhood assessed longitudinally from birth are found to be related to each other.
C URRENT OPINION Pediatric asthma phenotypes
TLDR
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Filaggrin Mutations and the Atopic March
TLDR
Loss-of-function mutations in the filaggrin gene have commonly been described in patients with AD and are associated with an increased risk of atopic sensitization in these individuals leading to asthma and allergic rhinitis.
Filaggrin gene mutations and new SNPs in asthmatic patients: a cross-sectional study in a Spanish population
TLDR
In the association study of genetic variants of the FLG gene in a population of patients diagnosed with asthma the 1741A > T polymorphism seems to be associated with non-allergic asthma.
Meta-analysis of filaggrin polymorphisms in eczema and asthma: robust risk factors in atopic disease.
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References

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Filaggrin null mutations are associated with increased asthma severity in children and young adults.
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TLDR
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