Filaggrin mutations may confer susceptibility to chronic hand eczema characterized by combined allergic and irritant contact dermatitis

@article{Molin2009FilaggrinMM,
  title={Filaggrin mutations may confer susceptibility to chronic hand eczema characterized by combined allergic and irritant contact dermatitis},
  author={S. Molin and S. Vollmer and E. Weiss and T. Ruzicka and J. Prinz},
  journal={British Journal of Dermatology},
  year={2009},
  volume={161}
}
Background  The pathogenesis of chronic hand eczema (CHE) is multifactorial and involves both endogenous predisposition and environmental triggers. 
Filaggrin mutations are strongly associated with contact sensitization in individuals with dermatitis
Background. Although heterozygous filaggrin gene (FLG) mutation carriers seem to have an increased risk of atopic, irritant and allergic nickel dermatitis, it remains unclear whether the risk ofExpand
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TLDR
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The successful treatment of hand dermatitis (HD) depends less on the selection of the proper topical steroid or a particular systemic agent than on addressing any underlying cause or perpetuatingExpand
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