Filaggrin mutations in the onset of eczema, sensitization, asthma, hay fever and the interaction with cat exposure.

@article{Schuttelaar2009FilaggrinMI,
  title={Filaggrin mutations in the onset of eczema, sensitization, asthma, hay fever and the interaction with cat exposure.},
  author={M L A Schuttelaar and M Kerkhof and Marcel F. Jonkman and Gerard H Koppelman and Bert A Brunekreef and Johan C. de Jongste and Alet H. Wijga and William-Henry-Irwin McLean and Dirkje S Postma},
  journal={Allergy},
  year={2009},
  volume={64 12},
  pages={1758-65}
}
BACKGROUND Filaggrin gene (FLG) mutations contribute to the development of eczema and asthma, but their contribution to sensitization and hay fever remains unclear. METHODS FLG mutations R501X, 2282del4 and R2447X were genotyped in the Prevention and Incidence of Asthma and Mite Allergy birth cohort (n = 934) to evaluate longitudinally, for up to 8 years, their association with eczema, sensitization, asthma, hay fever and their interaction with cat exposure. RESULTS The combined FLG… CONTINUE READING