Filaggrin loss-of-function mutations are associated with enhanced expression of IL-1 cytokines in the stratum corneum of patients with atopic dermatitis and in a murine model of filaggrin deficiency

@inproceedings{Kezic2012FilaggrinLM,
  title={Filaggrin loss-of-function mutations are associated with enhanced expression of IL-1 cytokines in the stratum corneum of patients with atopic dermatitis and in a murine model of filaggrin deficiency},
  author={Sanja Kezic and Gr{\'a}inne M. O’Regan and Ren{\'e} Lutter and Ivone Jakasa and Ellen S Koster and Sean P Saunders and Peter Caspers and Patrick M.J.H. Kemperman and Gerwin J. Puppels and Aileen Sandilands and Huijia Chen and Linda E Campbell and Karin Kroboth and Rosemarie M. Watson and Padraic G Fallon and W H Irwin McLean and Alan D Irvine},
  booktitle={The Journal of allergy and clinical immunology},
  year={2012}
}
BACKGROUND Filaggrin (FLG) mutations result in reduced stratum corneum (SC) natural moisturizing factor (NMF) components and consequent increased SC pH. Because higher pH activates SC protease activity, we hypothesized an enhanced release of proinflammatory IL-1 cytokines from corneocytes in patients with atopic dermatitis (AD) with FLG mutations (AD(FLG)) compared with that seen in patients with AD without these mutations (AD(NON-FLG)). OBJECTIVES We sought to investigate SC IL-1 cytokine… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 79 CITATIONS, ESTIMATED 39% COVERAGE

The Genetics and Epigenetics of Atopic Dermatitis—Filaggrin and Other Polymorphisms

  • Clinical Reviews in Allergy & Immunology
  • 2015
VIEW 8 EXCERPTS
CITES BACKGROUND & RESULTS
HIGHLY INFLUENCED

Skin barrier in atopic dermatitis.

  • Frontiers in bioscience
  • 2014
VIEW 4 EXCERPTS
CITES BACKGROUND

Epithelial barrier repair and prevention of allergy.

  • The Journal of clinical investigation
  • 2019
VIEW 1 EXCERPT
CITES BACKGROUND

Atopic dermatitis

VIEW 1 EXCERPT
CITES BACKGROUND

FILTER CITATIONS BY YEAR

2012
2019

CITATION STATISTICS

  • 3 Highly Influenced Citations

  • Averaged 10 Citations per year from 2017 through 2019

References

Publications referenced by this paper.
SHOWING 1-10 OF 63 REFERENCES

Abnormal skin barrier in the etiopathogenesis of atopic dermatitis

  • Current allergy and asthma reports
  • 2009
VIEW 6 EXCERPTS
HIGHLY INFLUENTIAL

Immunological and inflammatory functions of the interleukin-1 family.

  • Annual review of immunology
  • 2009
VIEW 7 EXCERPTS
HIGHLY INFLUENTIAL

IL-1 beta activation in human epidermis.

VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL