Filaggrin in the frontline: role in skin barrier function and disease.

  title={Filaggrin in the frontline: role in skin barrier function and disease.},
  author={Aileen Sandilands and Calum Sutherland and Alan D Irvine and William-Henry-Irwin McLean},
  journal={Journal of cell science},
  volume={122 Pt 9},
Recently, loss-of-function mutations in FLG, the human gene encoding profilaggrin and filaggrin, have been identified as the cause of the common skin condition ichthyosis vulgaris (which is characterised by dry, scaly skin). These mutations, which are carried by up to 10% of people, also represent a strong genetic predisposing factor for atopic eczema, asthma and allergies. Profilaggrin is the major component of the keratohyalin granules within epidermal granular cells. During epidermal… CONTINUE READING


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