Filaggrin gene mutations in African Americans with both ichthyosis vulgaris and atopic dermatitis.

@article{Polcari2014FilaggrinGM,
  title={Filaggrin gene mutations in African Americans with both ichthyosis vulgaris and atopic dermatitis.},
  author={Ingrid C Polcari and Lauren K Becker and Sarah L. Stein and Marilyn S. Smith and Amy Paller},
  journal={Pediatric dermatology},
  year={2014},
  volume={31 4},
  pages={489-92}
}
Atopic dermatitis (AD) and ichthyosis vulgaris (IV) are two common disorders of epidermal homeostasis resulting in dry skin. The profilaggrin gene, located on chromosome 1q22, encodes a keratin filament aggregating protein (filaggrin) that is essential to forming the epidermal barrier and maintaining hydration. Null mutations in filaggrin have been found to underlie IV and are common in patients with AD, but the minority of African Americans with AD or IV show these mutations in filaggrin. We… CONTINUE READING
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