FilGAP, a Rho- and ROCK-regulated GAP for Rac binds filamin A to control actin remodelling

@article{Ohta2006FilGAPAR,
  title={FilGAP, a Rho- and ROCK-regulated GAP for Rac binds filamin A to control actin remodelling},
  author={Yasutaka Ohta and John H. Hartwig and Thomas Peter Stossel},
  journal={Nature Cell Biology},
  year={2006},
  volume={8},
  pages={803-814}
}
FilGAP is a newly recognized filamin A (FLNa)-binding RhoGTPase-activating protein. The GTPase-activating protein (GAP) activity of FilGAP is specific for Rac and FLNa binding targets FilGAP to sites of membrane protrusion, where it antagonizes Rac in vivo. Dominant-negative FilGAP constructs lacking GAP activity or knockdown of endogenous FilGAP by small interference RNA (siRNA) induce spontaneous lamellae formation and stimulate cell spreading on fibronectin. Knockdown of endogenous FilGAP… CONTINUE READING
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