Fijiolides A and B, inhibitors of TNF-alpha-induced NFkappaB activation, from a marine-derived sediment bacterium of the genus Nocardiopsis.

@article{Nam2010FijiolidesAA,
  title={Fijiolides A and B, inhibitors of TNF-alpha-induced NFkappaB activation, from a marine-derived sediment bacterium of the genus Nocardiopsis.},
  author={Sang-Jip Nam and Susana P. Gaud{\^e}ncio and Christopher A. Kauffman and Paul Robert Jensen and Tamara P Kondratyuk and Laura E Marler and John M Pezzuto and William Fenical},
  journal={Journal of natural products},
  year={2010},
  volume={73 6},
  pages={1080-6}
}
Fijiolide A, a potent inhibitor of TNF-alpha-induced NFkappaB activation, along with fijiolide B, were isolated from a marine-derived bacterium of the genus Nocardiopsis. The planar structures of fijiolides A (1) and B (2) were elucidated by interpretation of 2D NMR spectroscopic data, while the absolute configurations of these compounds were defined by interpretation of circular dichroism and 2D NMR data combined with application of the advanced Mosher's method. Fijiolides A and B are related… CONTINUE READING

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