Fighting infection: the role of lipopolysaccharide binding proteins CD14 and LBP.

@article{Schuett1999FightingIT,
  title={Fighting infection: the role of lipopolysaccharide binding proteins CD14 and LBP.},
  author={Christine Schuett},
  journal={Pathobiology : journal of immunopathology, molecular and cellular biology},
  year={1999},
  volume={67 5-6},
  pages={227-9}
}
An invading pathogen must be held in check by the innate immune system until a specific immune response is mounted. Nonclonal pattern recognition receptors like CD14 or lipopolysaccharide (LPS) binding protein (LBP) recognize ubiquitous pathogen-associated molecular patterns, e.g. LPS. LBP mediates the binding of minute amounts of LPS to membrane-bound CD14 (mCD14) triggering a proinflammatory response of macrophages, which is crucial for keeping an infection under control. Moreover, in vitro… CONTINUE READING

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