Fighting Viral Infections and Virus-Driven Tumors with Cytotoxic CD4+ T Cells

@inproceedings{Muraro2017FightingVI,
  title={Fighting Viral Infections and Virus-Driven Tumors with Cytotoxic CD4+ T Cells},
  author={Elena Muraro and Anna Merlo and Debora Martorelli and Michela Cangemi and Silvia Dalla Santa and Riccardo Dolcetti and Antonio Rosato},
  booktitle={Front. Immunol.},
  year={2017}
}
CD4+ T cells have been and are still largely regarded as the orchestrators of immune responses, being able to differentiate into distinct T helper cell populations based on differentiation signals, transcription factor expression, cytokine secretion, and specific functions. Nonetheless, a growing body of evidence indicates that CD4+ T cells can also exert a direct effector activity, which depends on intrinsic cytotoxic properties acquired and carried out along with the evolution of several… CONTINUE READING