Fighting Fire with Fire: Is it Time to Use Probiotics to Manage Pathogenic Bacterial Diseases?

@article{Heineman2012FightingFW,
  title={Fighting Fire with Fire: Is it Time to Use Probiotics to Manage Pathogenic Bacterial Diseases?},
  author={John L. Heineman and Sara Bubenik and Stephen A McClave and Robert G. Martindale},
  journal={Current Gastroenterology Reports},
  year={2012},
  volume={14},
  pages={343-348}
}
Probiotics, when considered in clinical practice, have traditionally been used for prophylaxis; however, there is growing data suggesting treatment benefits in numerous disease states. In this review, we focus on probiotics as treatment for and prevention of several acute and chronic infectious processes including Helicobacter pylori, Clostridium difficile, necrotizing enterocolitis, ventilator-associated pneumonia, vancomycin-resistant enterococci, and nonalcoholic fatty liver disease. It is… 
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Use for probiotics in prevention and treatment is focused on, current concerns regarding their use are addressed, and a protocol for safe use of probiotics is proposed in the critically ill patient is proposed.
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Probiotic safety, the therapeutic properties of probiotics, the probiotic strains used and the action of the probiotics mechanism are reviewed, and the therapeutic effects of probiotic treatment procedures for VAP are compared to those of antibiotics.
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Appraisal Of Probiotics And Prebiotics In Gastrointestinal Infections
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It is hypothesized that alterations in the microbiome interfere with immune system maturation, resulting in impairment of IgA production, reduced abundance of regulatory T cells, and Th2-skewing of baseline immune responses which drive aberrant responses to innocuous (food) antigens.
Genetic and Metabolic Signals during Acute Enteric Bacterial Infection Alter the Microbiota and Drive Progression to Chronic Inflammatory Disease.
Colonization with Escherichia coli EC 25 protects neonatal rats from necrotizing enterocolitis
TLDR
E. coli EC 25, which was originally isolated from healthy rats, efficiently colonized the intestine and protected from NEC following introduction to newborn rats with formula at 106 or 108 cfu.
Vaccine against Helicobacter pylori: Inevitable approach.
TLDR
A route is drawn to define the best adopted strategy against this rogue bacterium, and the best reasonable and logical approach is to recommend prophylactic H. pylori vaccine among children as an obligatory national program to limit primary colonization.
Vaccine against Helicobacter pylori: Inevitable approach.
TLDR
A route is drawn to define the best adopted strategy against this rogue bacterium, and the best reasonable and logical approach is to recommend prophylactic H. pylori vaccine among children as an obligatory national program to limit primary colonization.
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