Fifty years of research onN-acetyl-2-aminofluorene, one of the most versatile compounds in experimental cancer research

@article{Kriek1992FiftyYO,
  title={Fifty years of research onN-acetyl-2-aminofluorene, one of the most versatile compounds in experimental cancer research},
  author={Erik Kriek},
  journal={Journal of Cancer Research and Clinical Oncology},
  year={1992},
  volume={118},
  pages={481-489}
}
It is just about 50 years since the publication of the report on the toxicity and carcinogenicity of the potent carcinogenN-acetyl-2-aminofluorene (AAF). In 1940 very few reports on the carcinogenic activity of chemical compounds in experimental animals were available. The discovery of pure chemicals as carcinogens, such as AAF, azo dyes and benzo[a]pyrene, provided cancer researchers with a number of tools whereby the progressive changes involved in the induction of cancer could be studied in… CONTINUE READING