Fifty years ago: The quest for steroid hormone receptors

  title={Fifty years ago: The quest for steroid hormone receptors},
  author={Guy G. Rousseau},
  journal={Molecular and Cellular Endocrinology},
  • G. Rousseau
  • Published 15 August 2013
  • Biology
  • Molecular and Cellular Endocrinology
Steroids and Autoimmunity.
This chapter addresses the structure and function of steroidal hormones involved in the neuroendocrine immune network and the ways in which endocrine and immune systems influence each other, in a bi-directional fashion.
Treatment with Synthetic Glucocorticoids and the Hypothalamus-Pituitary-Adrenal Axis
There is a considerable variation in individual physiology, probably related to different genetic profiles which regulate GC receptor activity, which may represent an interesting basis for possible future research fields.
G-protein αq participates in the steroid hormone 20-hydroxyecdysone nongenomic signal transduction
Enzymes for ecdysteroid biosynthesis: their biological functions in insects and beyond
This review summary summarizes the latest knowledge of enzymes crucial for synthesizing ecdysteroids, the principal insect steroid hormones, and discusses the functional conservation and diversity of Ecdysteroidogenic enzymes in other insects and even non-insect species, such as nematodes, vertebrates, and lower eukaryotes.
Recent progress in understanding the role of ecdysteroids in adult insects: Germline development and circadian clock in the fruit fly Drosophila melanogaster
This review focuses on very recent progress in the understanding of two adult biological events that require ecdysteroid biosynthesis and/or signaling in Drosophila at the molecular level: germline development and the circadian clock.
Modulation of innate immune response to viruses including SARS-CoV-2 by progesterone
The findings reveal how progesterone modulates host innate antiviral response, and point to progester one as a potential immunomodulatory reagent for infectious and inflammatory diseases.
Physiological basis for the etiology, diagnosis, and treatment of adrenal disorders: Cushing's syndrome, adrenal insufficiency, and congenital adrenal hyperplasia.
An understanding of the dynamics of the HPA axis is necessary to master the diagnosis and differential diagnosis of pituitary-adrenal diseases and giving great insight into its normal control.
Régulation de l’activité transcriptionnelle des récepteurs des estrogènes (ER) par le récepteur à chimiokine CXCR4 et les récepteurs à activité tyrosine kinase ErbB2 et ErbB3
A positive regulatory loop between CXCR4/SDF1 signaling pathway and ER transcriptional competence in human breast cancer cells is described and the impact of membrane receptors signaling on ER transcriptionnal response in breast cancer Cells is identified and characterized.


New Concepts on the Mode of Action of Hormones
  • P. Karlson
  • Chemistry
    Perspectives in biology and medicine
  • 1963
The future of hormone research will be in large part bound up with the advances in general biochemistry and physiology, and the accumulation of knowledge now available means that much progress along these lines is now possible.
The steroid and thyroid hormone receptor superfamily.
A superfamily of regulatory proteins that include receptors for thyroid hormone and the vertebrate morphogen retinoic acid is identified, suggesting mechanisms underlying morphogenesis and homeostasis may be more ubiquitous than previously expected.
The hormone-gene thesis so dominates the authors' contemporary conceptual framework that the effects of steroid hormones on metabolism are restricted to the single theme of steroid hormone regulation of gene activity, which provides the conceptual "breakthrough" required to elucidate the long-sought-for molecular basis for steroid hormone action.
Structure and regulation of the glucocorticoid hormone receptor
  • G. Rousseau
  • Biology, Chemistry
    Molecular and Cellular Endocrinology
  • 1984
Glucocorticoid receptors: relations between steroid binding and biological effects.
Gene regulation by steroid hormones.
Oestradiol induction of a glucocorticoid-responsive gene by a chimaeric receptor
It is shown that point mutations replacing two cysteines by two histidines in the first potential DNA-binding finger of the human oestrogen receptor (hER) prevent it from activating gene transcription, and region C determines the receptor's specificity for target genes.
Characterization of a steroid hormone receptor gene and mRNA in wild-type and mutant cells
Cloned complementary DNA (cDNA) for the rat liver glucocorticoid receptor is cloned and appears to be encoded by a single-copy gene which specifies a ∼6-kb transcript in rat and mouse cells; this mRNA is altered quantitatively and qualitatively in several mutant cell lines with specific defects in receptor function.
The nuclear receptor ligand-binding domain: structure and function.
Stimulation by aldosterone of a rapidly labelled RNA fraction in toad bladder tissue.