Fifty ways to make a neuron: shifts in stem cell hierarchy and their implications for neuropathology and CNS repair.

@article{Wernig2002FiftyWT,
  title={Fifty ways to make a neuron: shifts in stem cell hierarchy and their implications for neuropathology and CNS repair.},
  author={Marius Wernig and Oliver Bruestle},
  journal={Journal of neuropathology and experimental neurology},
  year={2002},
  volume={61 2},
  pages={101-10}
}
During embryogenesis, the developmental potential of individual cells is continuously restricted. While embryonic stem (ES) cells derived from the inner cell mass of the blastocyst can give rise to all tissues and cell types, their progeny segregates into a multitude of tissue-specific stem and progenitor cells. Following organogenesis, a pool of resident… CONTINUE READING