Fifteen years of gene therapy based on chimeric antigen receptors: "are we nearly there yet?".


"T-body" or chimeric antigen receptor (CAR) technology, which combines the specificity of an antibody with the homing, tissue penetration, and target cell destruction of T cells, was first described in 1993. After many years of unmet promise, significant improvements in gene transfer, including the development of efficient retroviral vectors for… (More)
DOI: 10.1089/hum.2009.142


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