Field trials of tuberculosis vaccines: how could we have done them better?

@article{Comstock1994FieldTO,
  title={Field trials of tuberculosis vaccines: how could we have done them better?},
  author={George W. Comstock},
  journal={Controlled clinical trials},
  year={1994},
  volume={15 4},
  pages={
          247-76
        }
}
Nineteen controlled trials of vaccination against tuberculosis are reviewed. Most involved very large numbers of participants and represented a wide variety of geographic and socioeconomic conditions. The trials were conducted under field conditions that sometimes verged on the primitive. Length of follow-up for tuberculosis ranged from 3 to 23 years, and up to 28 years for cancer. Under these circumstances, compromises and mistakes were made along with notable successes. With the current… CONTINUE READING

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