Field-collected permethrin-resistant Aedes aegypti from central Thailand contain point mutations in the domain IIS6 of the sodium channel gene (KDR).

@article{Srisawat2012FieldcollectedPA,
  title={Field-collected permethrin-resistant Aedes aegypti from central Thailand contain point mutations in the domain IIS6 of the sodium channel gene (KDR).},
  author={Raweewan Srisawat and Narumon Komalamisra and Chamnarn Apiwathnasorn and Pungasem Paeporn and Sittiruk Roytrakul and Yupha Rongsriyam and Yuki Eshita},
  journal={The Southeast Asian journal of tropical medicine and public health},
  year={2012},
  volume={43 6},
  pages={1380-6}
}
One of the mechanisms responsible for pyrethroid resistance in mosquitoes is mutations in domain IIS6 of voltage-gated sodium channel gene (kdr). Aedes aegypti larvae were collected from the central provinces of Thailand (Bangkok, Prachin Buri and Ratchaburi) and colonized until they became adults. Partial fragment of kdr of permethrin-resistant mosquitoes were amplified by RT-PCR and sequenced. Among the four nucleotide mutations detected, two mutations resulted in two amino acid substitutions… CONTINUE READING

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