Field cancerization in the colon: a role for aberrant DNA methylation?

  title={Field cancerization in the colon: a role for aberrant DNA methylation?},
  author={Yanxin Luo and Ming Yu and William M. Grady},
  booktitle={Gastroenterology report},
Colorectal cancer is the third most common cancer worldwide and arises secondary to the progressive accumulation of genetic and epigenetic alterations in normal colon cells, which results in a polyp-to-cancer progression sequence. It is known that individuals with a personal history of colon adenomas or cancer are at increased risk for metachronous colon neoplasms. One explanation for this increased risk could be field cancerization, which is a phenomenon in which the histologically normal… CONTINUE READING

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