Fidelity of RNA polymerase II transcription: Role of Rpb9 [corrected] in error detection and proofreading.

@article{Knippa2013FidelityOR,
  title={Fidelity of RNA polymerase II transcription: Role of Rpb9 [corrected] in error detection and proofreading.},
  author={Kevin C Knippa and David Owen Peterson},
  journal={Biochemistry},
  year={2013},
  volume={52 44},
  pages={
          7807-17
        }
}
The role of the small RNA polymerase II subunit Rpb9 in transcriptional proofreading was assessed in vitro. Transcription elongation complexes in which the 3' end of the RNA is not complementary to the DNA template have a dramatically reduced rate of elongation, which provides a fidelity checkpoint at which the error can be removed. The efficiency of such proofreading depends on competing rates of error propagation (extending the RNA chain without removing the error) and error excision, a… CONTINUE READING