Fidelity of HIV-1 reverse transcriptase copying a hypervariable region of the HIV-1 env gene.

@article{Ji1994FidelityOH,
  title={Fidelity of HIV-1 reverse transcriptase copying a hypervariable region of the HIV-1 env gene.},
  author={Jing-hui Ji and L. A. Loeb},
  journal={Virology},
  year={1994},
  volume={199 2},
  pages={323-30}
}
The unusually high mutation frequency exhibited by the human immunodeficiency virus (HIV) is a major impediment to developing effective vaccines against the virus and to designing analogs that inhibit viral replication. To investigate the molecular basis of HIV hypermutability, we established cell-free assays to measure the fidelity of HIV-1 reverse transcriptase (RT) in copying either DNA or both RNA and DNA templates that contain the hypervariable region 1 of the HIV-1 env gene (V-1). The… CONTINUE READING

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