Fibulin-3-mediated inhibition of epithelial-to-mesenchymal transition and self-renewal of ALDH+ lung cancer stem cells through IGF1R signaling

@article{Kim2014Fibulin3mediatedIO,
  title={Fibulin-3-mediated inhibition of epithelial-to-mesenchymal transition and self-renewal of ALDH+ lung cancer stem cells through IGF1R signaling},
  author={In-Gyu Kim and Su Young Kim and Soo Im Choi and Ji Hyun Lee and Kuk Chan Kim and Eun Wie Cho},
  journal={Oncogene},
  year={2014},
  volume={33},
  pages={3908-3917}
}
Fibulins (FBLNs), a family of extracellular matrix proteins, have recently been shown to act as tumor suppressors or activators in different cancers, and the underlying molecular mechanisms of their action in cancer remain unclear. We have previously shown that the expression of FBLN3 is suppressed by promoter hypermethylation and is associated with invasiveness in aggressive non-small cell lung cancer. In this study, we evaluated the roles and signaling mechanism of FBLN3 in lung cancer stem… CONTINUE READING
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