Fibrous and protoplasmic astrocytes are biochemically and developmentally distinct.

  title={Fibrous and protoplasmic astrocytes are biochemically and developmentally distinct.},
  author={Robert H. Miller and Martin C. Raff},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={4 2},
We have studied semithin frozen sections of developing and adult rat central nervous system (CNS) by indirect immunofluorescence in order to determine the antigenic phenotype of protoplasmic and fibrous astrocytes. Using antibodies against glial fibrillary acidic protein (GFAP) to identify astrocytes, we show that the great majority of fibrous astrocytes in adult optic nerve are labeled by the monoclonal antibody A2B5, while the great majority of protoplasmic astrocytes in adult cerebral cortex… CONTINUE READING
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