Fibrotic response as a distinguishing feature of resistance and susceptibility to pulmonary infection with Mycobacterium tuberculosis in mice.

@article{Marquis2008FibroticRA,
  title={Fibrotic response as a distinguishing feature of resistance and susceptibility to pulmonary infection with Mycobacterium tuberculosis in mice.},
  author={Jean-François Marquis and Andr{\'e} Nantel and Ronald Lacourse and Lynn Ryan and Robert J. North and Philippe Gros},
  journal={Infection and immunity},
  year={2008},
  volume={76 1},
  pages={
          78-88
        }
}
The differential susceptibility of inbred mouse strains DBA/2J (susceptible) and C57BL/6J (resistant) to pulmonary tuberculosis following aerosol infection is under complex genetic control. In this report, transcriptional profiling with RNAs from Mycobacterium tuberculosis-infected lungs was used to investigate the physiological response, cell type, and biochemical pathways underlying differential susceptibility to infection. Statistical analysis of cDNA-based microarrays revealed that 1,097… CONTINUE READING

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