Fibrosis is a key inhibitor of lymphatic regeneration.

  title={Fibrosis is a key inhibitor of lymphatic regeneration.},
  author={Tomer Avraham and Nicholas W Clavin and Sanjay V. Daluvoy and John Fernandez and M das Graças A Soares and Andrew P Cordeiro and Babak J. Mehrara},
  journal={Plastic and reconstructive surgery},
  volume={124 2},
BACKGROUND Lymphedema is a common debilitating sequela of lymph node dissection. Although numerous clinical studies suggest that factors that lead to fibrosis are associated with the development of lymphedema, this relationship has not been proven. The purpose of these experiments was therefore to evaluate lymphatic regeneration in the setting of variable soft-tissue fibrosis. METHODS A section of mouse tail skin including the capillary and collecting lymphatics was excised. Experimental… CONTINUE READING
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