Fibrosis in hypertensive heart disease: role of the renin-angiotensin-aldosterone system.

@article{Gonzlez2004FibrosisIH,
  title={Fibrosis in hypertensive heart disease: role of the renin-angiotensin-aldosterone system.},
  author={Arantxa Gonz{\'a}lez and Bego{\~n}a Soler L{\'o}pez and J M Olivares D{\'i}ez},
  journal={The Medical clinics of North America},
  year={2004},
  volume={88 1},
  pages={83-97}
}
Structural homogeneity of cardiac tissue is governed by mechanical and humoral factors that regulate cell growth, apoptosis, phenotype, and extracellular matrix turnover. ANGII has endocrine, autocrine, and paracrine properties that influence the behavior of cardiac cells and matrix by AT1 receptor binding. Various paradigms have been suggested, including ANGII-mediated up-regulation of collagen types I and III formation and deposition in cardiac conditions, such as HHD. A growing body of… CONTINUE READING