Fibrosis in diabetes complications: Pathogenic mechanisms and circulating and urinary markers

@article{Ban2008FibrosisID,
  title={Fibrosis in diabetes complications: Pathogenic mechanisms and circulating and urinary markers},
  author={Camelia R Ban and Stephen Morris Twigg},
  journal={Vascular Health and Risk Management},
  year={2008},
  volume={4},
  pages={575 - 596}
}
Diabetes mellitus is characterized by a lack of insulin causing elevated blood glucose, often with associated insulin resistance. Over time, especially in genetically susceptible individuals, such chronic hyperglycemia can cause tissue injury. One pathological response to tissue injury is the development of fibrosis, which involves predominant extracellular matrix (ECM) accumulation. The main factors that regulate ECM in diabetes are thought to be pro-sclerotic cytokines and protease/anti… CONTINUE READING
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