Fibrosis in Preeclamptic Placentas Is Associated with Stromal Fibroblasts Activated by the Transforming Growth Factor-β1 Signaling Pathway.

@article{OhmaruNakanishi2018FibrosisIP,
  title={Fibrosis in Preeclamptic Placentas Is Associated with Stromal Fibroblasts Activated by the Transforming Growth Factor-β1 Signaling Pathway.},
  author={Takako Ohmaru-Nakanishi and Kazuo Asanoma and Mai Fujikawa and Yasuyuki Fujita and Hiroshi Yagi and Ichiro Onoyama and Nobuhiro Hidaka and Kenzo Sonoda and Kiyoko Kato},
  journal={The American journal of pathology},
  year={2018},
  volume={188 3},
  pages={683-695}
}
Although fibrosis is one of the most prominent pathologic features of preeclamptic (PE) placentas, its mechanism remains largely unknown. Consistent with previous reports, we observed overexpression of collagen; actin, α2, smooth muscle, aorta; connective tissue growth factor; and fibronectin in PE placentas compared with control ones. To investigate the… CONTINUE READING