Fibrosis in Chronic Hepatitis C Acquired in Infancy: Is It Only a Matter of Time?

  title={Fibrosis in Chronic Hepatitis C Acquired in Infancy: Is It Only a Matter of Time?},
  author={Maria Guido and Flavia Bortolotti and Gioacchino Leandro and P. Galindo Jara and Loreto Hierro and Javier Larrauri and Cristiana Barbera and Raffaella Giacchino and Lucia Zancan and Fiorella Balli and Carlo Enrico Crivellaro and Emilio Cristina and Angela Pucci and M Rugge},
  journal={American Journal of Gastroenterology},
OBJECTIVE:The natural history of chronic hepatitis C acquired in infancy is not well understood. The progression of fibrosis was analyzed in untreated children with chronic hepatitis C virus infection and no other hepatotoxic cofactors.METHODS:A total of 112 pediatric patients (13 with paired liver biopsies) were considered. Fibrosis was assessed by METAVIR score (i.e., stage F1 to F4). The ratio between the stage of fibrosis (METAVIR units) and the presumed duration of infection represented… CONTINUE READING


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