Fibrosis and heart failure

@article{Segura2012FibrosisAH,
  title={Fibrosis and heart failure},
  author={Ana Maria Segura and O. Howard Frazier and L. Maximilian Buja},
  journal={Heart Failure Reviews},
  year={2012},
  volume={19},
  pages={173-185}
}
The extracellular matrix (ECM) is a living network of proteins that maintains the structural integrity of the myocardium and allows the transmission of electrical and mechanical forces between the myocytes for systole and diastole. During ventricular remodeling, as a result of iterations in the hemodynamic workload, collagen, the main component of the ECM, increases and occupies the areas between the myocytes and the vessels. The resultant fibrosis (reparative fibrosis) is initially a… 
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267 Citations
Highly Influential Citations
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Results Citations
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267 Citations

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Mechanisms of Cardiac Fibrosis and Heart Failure
TLDR
The structure and function of the cardiac ECM from development to various pathological states is reviewed as well as new findings in the study of reverse cardiac remodelling following unloading of the left ventricle are highlighted.
Remodelling of the Cardiac Extracellular Matrix: Role of Collagen Degradation and Accumulation in Pathogenesis of Heart Failure
TLDR
An overview of the mechanisms involved in myocardial fibrosis, the disease-dependent nature and consequence of different types of Fibrosis, clinical biomarkers of collagen turnover, and potential therapeutic approaches in managing the myocardium are provided.
The fibrosis-cell death axis in heart failure
TLDR
The interaction between cardiac fibrosis, cardiomyocyte hypertrophy and cell death, and potential strategies for tackling progressive cardiac remodeling and HF are described.
Mechanisms of cardiac collagen deposition in experimental models and human disease.
The Soft- and Hard-Heartedness of Cardiac Fibroblasts: Mechanotransduction Signaling Pathways in Fibrosis of the Heart
TLDR
The current status of knowledge of mechanotransduction signaling pathways in cardiac fibroblasts that culminate in pro-fibrotic gene expression are reviewed.
Remodeling and Fibrosis of the Cardiac Muscle in the Course of Obesity—Pathogenesis and Involvement of the Extracellular Matrix
TLDR
Excessive collagen deposition in the extracellular matrix (ECM) in the course of obesity may increase the stiffness of the myocardium and thereby deteriorate the heart diastolic function and facilitate the occurrence of HFpEF.
Inhibitor of lysyl oxidase improves cardiac function and the collagen/MMP profile in response to volume overload.
TLDR
In conclusion, this study demonstrated key cardioprotective effects of LOX inhibition against adverse cardiac remodeling due to chronic VO and improved ventricular collagen and matrix metalloproteinase/tissue inhibitor of metalliproteinase profiles.
The complex dynamics of myocardial interstitial fibrosis in heart failure. Focus on collagen cross-linking.
Reprint of "The complex dynamics of myocardial interstitial fibrosis in heart failure. Focus on collagen cross-linking".
Cardiomyocyte damage control in heart failure and the role of the sarcolemma
TLDR
A novel perspective on sar colemma remodelling is presented by considering whether targeting proteins that regulate sarcolemma injury-repair may hold promise for developing new strategies to attenuate HF progression.
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