Fibrosis—a lethal component of systemic sclerosis

  title={Fibrosis—a lethal component of systemic sclerosis},
  author={Yuen Yee Ho and David Lagares and Andrew M Tager and Mohit Kapoor},
  journal={Nature Reviews Rheumatology},
Fibrosis is a pathological process characterized by excessive accumulation of connective tissue components in an organ or tissue. Fibrosis is produced by deregulated wound healing in response to chronic tissue injury or chronic inflammation, the hallmarks of rheumatic diseases. Progressive fibrosis, which distorts tissue architecture and results in progressive loss of organ function, is now recognized to be one of the major causes of morbidity and mortality in individuals with one of the most… CONTINUE READING
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lessons learned from populationbased and observational cohort studies

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