Fibrosing mediastinitis complicating prior histoplasmosis is associated with human leukocyte antigen DQB1*04:02 − a case control study

@inproceedings{Strock2015FibrosingMC,
  title={Fibrosing mediastinitis complicating prior histoplasmosis is associated with human leukocyte antigen DQB1*04:02 − a case control study},
  author={Stephen B Strock and Silvana Gaudieri and Simon A Mallal and Chang Yu and Daphne B. Mitchell and Joy Cogan and Wendi R. Mason and Deborah Crowe and James E Loyd},
  booktitle={BMC infectious diseases},
  year={2015}
}
BACKGROUND Fibrosing mediastinitis (FM) is an idiosyncratic reaction to infection with Histoplasma capsulatum with a prevalence of 3:100,000 people infected. The rarity of post-histoplasmosis fibrosing mediastinitis (PHFM) in areas where H. capsulatum is endemic suggests that an abnormal immunological host response may be responsible for the development of fibrosis. Our group previously reported an association between subjects with PHFM and human leukocyte antigen (HLA)-A*02. We sought to… CONTINUE READING
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